Hormonal dependence of adrenal cortical tumors of CE and BALB/c mice in serial intraocular transfer.
نویسنده
چکیده
MATERIALS AND METHODS The adrenal cortical tumors used, all arising in castrated males and, if already transplanted, being carried in castrated males (18), were: CE 1, the original neoplasm in a CE mouse; BALE 5880/1,1 a first-generation subcutaneous transplant in a BALB/c; B ALB 5880/2, a second-generation sub cutaneous transplant of the same tumor in a BALB/c; and CE 366/2, a second-generation sub cutaneous transplant in a CE mouse. Except as specified, all transfers were made into the anterior chambers of both eyes of groups of six to eight isologous hosts, 2-4 months of age, by the technic previously described (5). These hosts might be castrated or intact males or females. Most groups were castrated at the time of transfer,
منابع مشابه
Inhibition of growth of a transplanted adrenal cortical tumor by sex steroids.
Adrenal cortical carcinomas may be induced by early castration of male or female CE (~ , ~8) or BALB/c (6) mice. Such tumors are often hormonally dependent, i.e., they show faster growth as transplants in castrated than in intact hosts (8, 18). These dependent tumors enter a dormant, or latent, period of 1 or more months after intraocular transplantation, followed by a shorter one during which ...
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عنوان ژورنال:
- Cancer research
دوره 18 7 شماره
صفحات -
تاریخ انتشار 1958