Hormonal dependence of adrenal cortical tumors of CE and BALB/c mice in serial intraocular transfer.

MATERIALS AND METHODS The adrenal cortical tumors used, all arising in castrated males and, if already transplanted, being carried in castrated males (18), were: CE 1, the original neoplasm in a CE mouse; BALE 5880/1,1 a first-generation subcutaneous transplant in a BALB/c; B ALB 5880/2, a second-generation sub cutaneous transplant of the same tumor in a BALB/c; and CE 366/2, a second-generation sub cutaneous transplant in a CE mouse. Except as specified, all transfers were made into the anterior chambers of both eyes of groups of six to eight isologous hosts, 2-4 months of age, by the technic previously described (5). These hosts might be castrated or intact males or females. Most groups were castrated at the time of transfer,